This paper examines the dynamics of deindustrialization in developed countries during the 1970–2015 period, investigating the patterns and factors underlying manufacturing employment growth in 12 developed economies. The study discloses seven key findings with valuable policy insights. In particular, the paper shows that deindustrialization is a persistent pattern that experienced a significant structural change in the post-1990 period, in which the acceleration of globalization with the rise of North-South trade appeared to have a significant effect. Furthermore, industries with higher relative labour productivity are significantly more resistant to deindustrialization, particularly in the post-1990 period, and this effect is stronger for low-tech industries. In addition, deindustrialization tends to be more severe in countries with larger populations and a deficit-prone trade balance, and these links have become more pronounced in the post-1990 period.